Article
Cardiac Nestin+ Mesenchymal Stromal Cells Enhance Healing of Ischemic Heart through Periostin-Mediated M2 Macrophage Polarization.
Molecular therapy : the journal of the American Society of Gene Therapy - 4 Mar 2020
Liao Yan, Li Guilan, Zhang Xiaoran, Huang Weijun, Xie Dongmei, Dai Gang, Zhu Shuanghua, Lu Dihan, Zhang Zhongyuan, Lin Junyi, Wu Bingyuan, Lin Wanwen, Chen Yang, Chen Zhihong, Peng Chaoquan, Wang Maosheng, Chen Xinxin, Jiang Mei Hua, Xiang Andy Peng
Abstract excerpt
Mesenchymal stromal cells (MSCs) show potential for treating cardiovascular diseases, but their therapeutic efficacy exhibits significant heterogeneity depending on the tissue of origin. This study sought to identify an optimal source of MSCs for cardiovascular disease therapy. We demonstrated that Nestin was a suitable marker for cardiac MSCs (Nes+cMSCs), which were identified by their self-renewal ability,...
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