Article
A regulatory microRNA network controls endothelial cell phenotypic switch during sprouting angiogenesis.
eLife - 24 Jan 2020
Rosano Stefania, Corà Davide, Parab Sushant, Zaffuto Serena, Isella Claudio, Porporato Roberta, Hoza Roxana Maria, Calogero Raffaele A, Riganti Chiara, Bussolino Federico, Noghero Alessio
Abstract excerpt
Angiogenesis requires the temporal coordination of the proliferation and the migration of endothelial cells. Here, we investigated the regulatory role of microRNAs (miRNAs) in harmonizing angiogenesis processes in a three-dimensional in vitro model. We described a microRNA network which contributes to the observed down- and upregulation of proliferative and migratory genes, respectively. Global analysis of...
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