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Article

Colistin Combined With Tigecycline: A Promising Alternative Strategy to Combat Escherichia coli Harboring blaNDM–5 and mcr-1

8 Jan 2020

Abstract excerpt

Infections due to carbapenem-resistant NDM-producing Escherichia coli represent a major therapeutic challenge, especially in situations of pre-existing colistin resistance. The aim of this study was to investigate combinatorial pharmacodynamics of colistin and tigecycline against E. coli harboring blaNDM-5 and mcr-1, with possible mechanisms explored as well. Colistin disrupted the bacterial outer-membrane and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31969868
DOI: 10.3389/fmicb.2019.02957

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