Article
Impact of HSD17B13 rs72613567 genotype on hepatic decompensation and mortality in patients with portal hypertension.
Liver international : official journal of the International Association for the Study of the Liver - 1 Feb 2020
Scheiner Bernhard, Stättermayer Albert F, Schwabl Philipp, Bucsics Theresa, Paternostro Rafael, Bauer David, Simbrunner Benedikt, Schmidt Ralf, Marculescu Rodrig, Ferlitsch Arnulf, Peck-Radosavljevic Markus, Pinter Mathias, Trauner Michael, Reiberger Thomas, Ferenci Peter, Mandorfer Mattias
Abstract excerpt
BACKGROUND & AIMS: The loss-of-function rs72613567 T > TA-variant in the 17β-hydroxysteroid dehydrogenase 13 (HSD17B13) gene might protect from alcoholic and non-alcoholic fatty liver disease (ALD/NAFLD) and associated fibrosis/cirrhosis. We investigated the impact of the T > TA-variant on hepatic decompensation and mortality and investigated its implications on retinol and sex steroid metabolism in patients who...
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