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CSF SerpinA1 in Creutzfeldt–Jakob disease and frontotemporal lobar degeneration

20 Jan 2020

Abstract excerpt

Abstract Objective SerpinA1 (alpha‐1 antitrypsin) is an acute inflammatory protein, which seems to play a role in neurodegeneration and neuroinflammation. In Alzheimer’s disease and synucleinopathies, SerpinA1 is overexpressed in the brain and the cerebrospinal fluid (CSF) showing abnormal patterns of its charge isoforms. To date, no comprehensive studies explored SerpinA1 CSF isoforms in Creutzfeldt–Jakob...

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PMID: 31957347
DOI: 10.1002/acn3.50980

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