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Article

Impact of anticancer chemotherapy on the extension of beta-lactamase spectrum: an example with KPC-type carbapenemase activity towards ceftazidime-avibactam.

Scientific reports - 17 Jan 2020

Hobson Claire Amaris, Bonacorsi Stéphane, Hocquet Didier, Baruchel André, Fahd Mony, Storme Thomas, Tang Raksamy, Doit Catherine, Tenaillon Olivier, Birgy André

Abstract excerpt

Through their action on DNA replication, anticancer chemotherapies could increase the basal mutation rate in bacteria and increase the risk of selecting antibiotic resistant mutants. We investigated the impact of several drugs on a beta-lactamase model using KPC-type carbapenemase-producing Enterobacteriaceae. We studied the impact of anticancer chemotherapies used in pediatric hematologic malignancies on 7...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31953453
DOI: 10.1038/s41598-020-57505-w
PMCID: PMC6969056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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