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Article

Molecular Characterization of Differentiated-Resistance MSC Subclones by Single-Cell Transcriptomes

9 Mar 2022

Abstract excerpt

Background: The mechanism of tumorigenicity potentially evolved in mesenchymal stem cells (MSCs) remains elusive, resulting in inconsistent clinical application efficacy. We hypothesized that subclones in MSCs contribute to their tumorgenicity, and we approached MSC-subclones at the single-cell level. Methods: MSCs were cultured in an osteogenic differentiation medium and harvested on days 12, 19, and 25 for cell...

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PMID: 35356283
DOI: 10.3389/fcell.2022.699144

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