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Dengue virus and the complement alternative pathway

14 Jan 2020

Abstract excerpt

Dengue disease is an inflammatory-driven pathology, and complement overactivation is linked to disease severity and vascular leakage. Additionally, dysregulation of complement alternative pathway (AP) components has been described, such as upregulation of complement factor D and downregulation of complement factor H (FH), which activate and inhibit the AP, respectively. Thus, the pathology of severe dengue could...

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PMID: 31943152
DOI: 10.1002/1873-3468.13730

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