Back to search

Article

Dengue NS1 as a Driver of Immune-Mediated Pathogenesis

2026-04-03

Abstract excerpt

Dengue infection remains a major global health concern, with a subset of patients progressing from self-limited dengue fever to severe disease characterized by plasma leakage, shock, and organ dysfunction. The dengue non-structural protein 1 (NS1), a multifunctional glycoprotein expressed on infected cells and secreted into circulation, has emerged as a key mediator linking viral infection to immune-driven vascula...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
79727f31-639b-51ea-87b6-3e7cfb8356a4
DOI
10.20944/preprints202604.0254.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Dengue NS1 as a Driver of Immune-Mediated PathogenesisDOI 10.20944/preprints202604.0254.v1
Endothelial Dysfunction, HMGB1, and Dengue: An Enigma to SolveSemantic proximity
Recent advances in understanding dengueSemantic proximity
Dengue virus and the complement alternative pathwaySemantic proximity
Dengue virus NS1 leads to downregulation of HNF4 alpha in liver cells resulting in a decrease in coagulation factors I, V, X, and XIII, contributing to coagulopathySemantic proximity
Dengue and the Lectin Pathway of the Complement System.Semantic proximity
Yellow fever disease severity and endothelial dysfunction are associated with elevated serum levels of viral NS1 protein and syndecan-1Semantic proximity
Microparticles Released by Dengue Virus-Infected Monocytes Mediate Endothelial Viral Infection and VasculopathySemantic proximity
Robust immunogenic potential of N and C-terminal deleted variant of dengue virus NS1 protein (dNS1)Semantic proximity
The pathogenesis of dengue.Semantic proximity
DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junctionSemantic proximity
A Critical Role for Perivascular Cells in Amplifying Vascular Leakage Induced by Dengue Virus Nonstructural Protein 1Semantic proximity
Dengue overview: An updated systemic review.Semantic proximity
Select a neighboring publication to make it the new centre.