Article
Chronic IL-1β-induced inflammation regulates epithelial-to-mesenchymal transition memory phenotypes via epigenetic modifications in non-small cell lung cancer.
Scientific reports - 15 Jan 2020
Li Rui, Ong Stephanie L, Tran Linh M, Jing Zhe, Liu Bin, Park Stacy J, Huang Zi Ling, Walser Tonya C, Heinrich Eileen L, Lee Gina, Salehi-Rad Ramin, Crosson William P, Pagano Paul C, Paul Manash K, Xu Shili, Herschman Harvey, Krysan Kostyantyn, Dubinett Steven
Abstract excerpt
Chronic inflammation facilitates tumor progression. We discovered that a subset of non-small cell lung cancer cells underwent a gradually progressing epithelial-to-mesenchymal (EMT) phenotype following a 21-day exposure to IL-1β, an abundant proinflammatory cytokine in the at-risk for lung cancer pulmonary and the lung tumor microenvironments. Pathway analysis of the gene expression profile and in vitro...
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