Article
Glycine Cleavage System and cAMP Receptor Protein Co-Regulate CRISPR/cas3 Expression to Resist Bacteriophage.
Viruses - 13 Jan 2020
Yang Denghui, Wang Zhaofei, Ma Jingjiao, Fu Qiang, Wu Lifei, Wang Hengan, Wang Shaohui, Yan Yaxian, Sun Jianhe
Abstract excerpt
The CRISPR/Cas system protects bacteria against bacteriophage and plasmids through a sophisticated mechanism where cas operon plays a crucial role consisting of cse1 and cas3. However, comprehensive studies on the regulation of cas3 operon of the Type I-E CRISPR/Cas system are scarce. Herein, we investigated the regulation of cas3 in Escherichia coli. The mutation in gcvP or crp reduced the CRISPR/Cas system...
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