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Association of glomerular DNA damage and DNA methylation with one-year eGFR decline in IgA nephropathy

14 Jan 2020

Abstract excerpt

Accumulation of DNA double-strand breaks (DSBs) is linked to aging and age-related diseases. We recently reported the possible association of DNA DSBs with altered DNA methylation in murine models of kidney disease. However, DSBs and DNA methylation in human kidneys was not adequately investigated. This study was a cross-sectional observational study to evaluate the glomerular DNA DSB marker γH2AX and...

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PMID: 31937846
DOI: 10.1038/s41598-019-57140-0

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