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Efficient generation of thymic epithelium from induced pluripotent stem cells that prolongs allograft survival

14 Jan 2020

Abstract excerpt

The thymus plays a significant role in establishing immunological self-tolerance. Previous studies have revealed that host immune reaction to allogeneic transplants could be regulated by thymus transplantation. However, physiological thymus involution hinders the clinical application of these insights. Here, we report an efficient generation of thymic epithelial-like tissue derived from induced pluripotent stem...

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PMID: 31937817
DOI: 10.1038/s41598-019-57088-1

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