High risk genotypes for schizophrenia may have been adaptive in the context of smallpox.

Abstract excerpt

Schizophrenia is known to impair reproductive and occupational functioning, and thus, the condition would appear to be a poorly adaptive trait. In contrast to expectations, the high frequency of schizophrenia, coupled with the existence of differing but analogous high schizophrenia risk polymorphisms across the globe, suggest that high risk schizophrenia genotypes could have experienced some positive rather than...

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