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Developmental programming: prenatal testosterone-induced epigenetic modulation and its effect on gene expression in sheep ovary†

13 Jan 2020

Abstract excerpt

Maternal perturbations or sub-optimal conditions during fetal development can predispose the offspring to diseases in adult life. Animal and human studies show that prenatal androgen excess may be an underlying cause of polycystic ovary syndrome (PCOS) later in life. In women, PCOS is a common fertility disorder with comorbid metabolic dysfunction. Here, using a sheep model of PCOS phenotype, we elucidate the...

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PMID: 31930385
DOI: 10.1093/biolre/ioaa007

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