Article
Could perturbed fetal development of the ovary contribute to the development of polycystic ovary syndrome in later life?
PloS one - 1 Jan 2020
Hartanti Monica D, Rosario Roseanne, Hummitzsch Katja, Bastian Nicole A, Hatzirodos Nicholas, Bonner Wendy M, Bayne Rosemary A, Irving-Rodgers Helen F, Anderson Richard A, Rodgers Raymond J
Abstract excerpt
Polycystic ovary syndrome (PCOS) affects around 10% of young women, with adverse consequences on fertility and cardiometabolic outcomes. PCOS appears to result from a genetic predisposition interacting with developmental events during fetal or perinatal life. We hypothesised that PCOS candidate genes might be expressed in the fetal ovary when the stroma develops; mechanistically linking the genetics, fetal...
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