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Recent developments in self-resistance gene directed natural product discovery

1 Jan 2020

Abstract excerpt

Covering: 2000 to 2019Natural products (NPs) are important sources of human therapeutic agents and pesticides. To prevent self-harm from bioactive NPs, some microbial producers employ self-resistance genes to protect themselves. One effective strategy is to employ a self-resistance enzyme (SRE), which is a slightly mutated version of the original metabolic enzyme, and is resistant to the toxic NP but is still...

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PMID: 31912842
DOI: 10.1039/c9np00050j

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