Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Beneficial effect of ezetimibe-atorvastatin combination therapy in patients with a mutation in ABCG5 or ABCG8 gene.

Lipids in health and disease - 4 Jan 2020

Tada Hayato, Okada Hirofumi, Nomura Akihiro, Takamura Masayuki, Kawashiri Masa-Aki

Abstract excerpt

BACKGROUND: Use of ezetimibe on top of statin therapy has been shown to be effective to reduce LDL cholesterol level in hypercholesterolemic patients. However, little is known regarding the individual variety of the effectiveness of ezetimibe. We hypothesized that hypercholesterolemic patients with a mutation in ABCG5 or ABCG8 gene exhibit better response to ezetimibe than those without, based on the fact that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atorvastatin
Share to ATP Binding Cassette Transporter, Subfamily G, Member 5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily G, Member 8

Share to Cholesterol, LDL

Share to Drug Combinations

Share to Ezetimibe

Share to Hypercholesterolemia

Share to Lipoproteins

Source

Open in PubMed Open full text

Identifiers

PMID: 31901240
DOI: 10.1186/s12944-019-1183-4
PMCID: PMC6942309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beneficial effect of ezetimibe-atorvastatin combination therapy in patients with a mutation in ABCG5 or ABCG8 gene.PMID 31901240Read ↗

Children with Severe Hypercholesterolemia Caused by a Pathogenic Mutation in ABCG5.Semantic proximity Read ↗

Serum sitosterol level predicting ABCG5 or ABCG8 genetic mutations.Semantic proximity Read ↗

First case of sitosterolemia caused by double heterozygous mutations in ABCG5 and ABCG8 genes.Semantic proximity Read ↗

Rare and Deleterious Mutations in ABCG5/ABCG8 Genes Contribute to Mimicking and Worsening of Familial Hypercholesterolemia PhenotypeSemantic proximity Read ↗

Efficacy of alirocumab in 1191 patients with a wide spectrum of mutations in genes causative for familial hypercholesterolemia.Semantic proximity Read ↗

A Catalog of the Pathogenic Variants in ABCG5 and ABCG8 and Clinical Features in Sitosterolemia.Semantic proximity Read ↗

Clinical and Genetic Analysis of a Family With Sitosterolemia Caused by a Novel ATP-Binding Cassette Subfamily G Member 5 Compound Heterozygous MutationSemantic proximity Read ↗

Sitosterolemia: Twenty Years of Discovery of the Function of ABCG5ABCG8.Semantic proximity Read ↗

Genetic analysis and functional study of a novel ABCG5 mutation in sitosterolemia with hematologic disease.Semantic proximity Read ↗

CYP7A1 polymorphism influences the LDL cholesterol-lowering response to atorvastatin.Semantic proximity Read ↗

Timely diagnosis of sitosterolemia by next generation sequencing in two children with severe hypercholesterolemia.Semantic proximity Read ↗

Use of targeted exome sequencing in genetic diagnosis of Chinese familial hypercholesterolemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.