Article
Elevated HDAC activity and altered histone phospho-acetylation confer acquired radio-resistant phenotype to breast cancer cells.
Clinical epigenetics - 3 Jan 2020
Sharda Asmita, Rashid Mudasir, Shah Sanket Girish, Sharma Ajit Kumar, Singh Saurav Raj, Gera Poonam, Chilkapati Murali Krishna, Gupta Sanjay
Abstract excerpt
BACKGROUND: Poor-responsiveness of tumors to radiotherapy is a major clinical problem. Owing to the dynamic nature of the epigenome, the identification and targeting of potential epigenetic modifiers may be helpful to curb radio-resistance. This requires a detailed exploration of the epigenetic changes that occur during the acquirement of radio-resistance. Such an understanding can be applied for effective...
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