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Human Fetal Lungs Harbor a Microbiome Signature

3 Jan 2020

Abstract excerpt

COPD (11,12). RARB is expressed in human lung tissue, bronchial epithelial cells, and airway smooth muscle cells (10), and knockout of this gene could lead to premature alveolar septation in mice (13), suggesting its fundamental function in lung development, normal physiology, and capacity.In this study, we observed the positive association between PAH exposure and hypermethylation in RARB promoter; a putative...

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PMID: 31898918
DOI: 10.1164/rccm.201911-2127le

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