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Article

RAD21 inhibited transcription of tumor suppressor MIR4697HG and led to glioma tumorigenesis

26 Dec 2019

Abstract excerpt

BACKGROUND: Studies have revealed the aberrant expression of lncRNAs is responsible for human carcinogenesis. MIR4697 host gene (MIR4697HG) is an upregulated lncRNA that promoted cell growth and metastasis in other cancers. In this study, we tested the expression of MIR4697HG in glioma cells and detected the comparatively down-regulated expression. RAD1 is an upstream regulator for MIR4697HG. This study aimed at...

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PMID: 31884342
DOI: 10.1016/j.biopha.2019.109759

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