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PDRG1 promotes the proliferation and migration of GBM cells by the MEK/ERK/CD44 pathway

23 Nov 2021

Abstract excerpt

P53 and DNA damage-regulated gene1 (PDRG1) is overexpressed in diverse carcinomas. Here, we discover that PDRG1 is overexpressed in glioblastoma multiforme (GBM). However, the clinical significance, biological role, and underlying molecular mechanisms of PDRG1 in GBM remain unclear. PDRG1 was aberrantly overexpressed in glioma, especially prevalent in GBM, and correlated with poor clinicopathologic features of...

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Cancer, Hypoxia, and Metabolism
Glioma Diagnosis and Treatment
Neuroblastoma Research and Treatments

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34812552
DOI: 10.1111/cas.15214

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