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Article

An investigation into the modulation of T cell phenotypes by amitriptyline and nortriptyline.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Feb 2020

Royds Jonathan, Conroy Melissa J, Dunne Margaret R, McCrory Connail, Lysaght Joanne

Abstract excerpt

Amitriptyline is prescribed for treating the symptoms of neuroinflammatory disorders including neuropathic pain and fibromyalgia. As amitriptyline has evidence of modulating the neuroimmune interface; the effects of amitriptyline treatment on T-cell phenotype and function were examined in vitro. Peripheral blood mononuclear cells(PBMCs) were isolated and treated with amitriptyline, nortriptyline and a combination...

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Share to Antidepressive Agents, Tricyclic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 31882254
DOI: 10.1016/j.euroneuro.2019.12.106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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