Article
Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients.
Clinical epigenetics - 26 Dec 2019
Delacrétaz Aurélie, Glatard Anaïs, Dubath Céline, Gholam-Rezaee Mehdi, Sanchez-Mut Jose Vicente, Gräff Johannes, von Gunten Armin, Conus Philippe, Eap Chin B
Abstract excerpt
BACKGROUND: Metabolic side effects induced by psychotropic drugs represent a major health issue in psychiatry. CREB-regulated transcription coactivator 1 (CRTC1) gene plays a major role in the regulation of energy homeostasis and epigenetic mechanisms may explain its association with obesity features previously described in psychiatric patients. This prospective study included 78 patients receiving psychotropic...
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