Article
Influence of CRTC1 polymorphisms on body mass index and fat mass in psychiatric patients and the general adult population.
JAMA psychiatry - 1 Oct 2013
Choong Eva, Quteineh Lina, Cardinaux Jean-René, Gholam-Rezaee Mehdi, Vandenberghe Frederik, Dobrinas Maria, Bondolfi Guido, Etter Manuela, Holzer Laurent, Magistretti Pierre, von Gunten Armin, Preisig Martin, Vollenweider Peter, Beckmann Jacques S, Pralong François P, Waeber Gerard, Kutalik Zoltan, Conus Philippe, Bochud Murielle, Eap Chin B
Abstract excerpt
IMPORTANCE: There is a high prevalence of obesity in psychiatric patients, possibly leading to metabolic complications and reducing life expectancy. The CREB-regulated transcription coactivator 1 (CRTC1) gene is involved in energy balance and obesity in animal models, but its role in human obesity is unknown. OBJECTIVE: To determine whether polymorphisms within the CRTC1 gene are associated with adiposity markers...
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