Article
Analysis of Intestinal Metaplasia Without Dysplasia in the Urinary Bladder Reveal Only Rare Mutations Associated With Colorectal Adenocarcinoma.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2000
Amin Ali, Murati-Amador Belkiss, Lombardo Kara A, Jackson Cynthia L, Grada Zakaria, Palsgrove Doreen N, Matoso Andres
Abstract excerpt
Intestinal metaplasia (IM) is a rare finding in urinary bladder specimens. It is unclear whether IM without dysplasia is a precursor of malignancy in the urinary system. We retrospectively selected 9 cases of IM of bladder (1 case harboring high-grade dysplasia), and performed mutation analysis for genes frequently mutated in colon cancer including BRAF, APC, KRAS, MET, NRAS, PIK3CA, CTNNB1, FBXW7, and TP53 using...
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