Article
Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations.
Nature communications - 19 Dec 2019
Inoue Satoshi, Hirota Yasushi, Ueno Toshihide, Fukui Yamato, Yoshida Emiko, Hayashi Takuo, Kojima Shinya, Takeyama Reina, Hashimoto Taiki, Kiyono Tohru, Ikemura Masako, Taguchi Ayumi, Tanaka Tomoki, Tanaka Yosuke, Sakata Seiji, Takeuchi Kengo, Muraoka Ayako, Osuka Satoko, Saito Tsuyoshi, Oda Katsutoshi, Osuga Yutaka, Terao Yasuhisa, Kawazu Masahito, Mano Hiroyuki
Abstract excerpt
Uterine adenomyosis is a benign disorder that often co-occurs with endometriosis and/or leiomyoma, and impairs quality of life. The genomic features of adenomyosis are unknown. Here we apply next-generation sequencing to adenomyosis (70 individuals and 192 multi-regional samples), as well as co-occurring leiomyoma and endometriosis, and find recurring KRAS mutations in 26/70 (37.1%) of adenomyosis cases....
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