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Article

Screening of MYH7 gene mutation sites in hypertrophic cardiomyopathy and its significance.

Chinese medical journal - 5 Dec 2019

Liu Hui-Ting, Ji Fang-Fang, Wei Ling, Zuo An-Jun, Gao Yu-Xiu, Qi Lin, Jin Bu, Wang Ji-Gang, Zhao Peng

Abstract excerpt

BACKGROUND: There have been few reports of mutations in the beta-myosin heavy chain (MYH7) gene in hypertrophic cardiomyopathy (HCM), which is associated with sudden cardiac death caused by HCM. This study aimed to screen the mutation sites in the sarcomeric gene MYH7 in Chinese patients with HCM. We also planned to analyze the pathogenicity of the mutation site as well as its significance in clinical and...

Topics

Adolescent
Adult
Cardiac Myosins
Cardiomyopathy, Hypertrophic
Computational Biology
Exons
Female
Humans
Male
Middle Aged
Mutation
Myosin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pedigree

Phenotype

Sequence Analysis, DNA

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 31856055
DOI: 10.1097/CM9.0000000000000428
PMCID: PMC6940073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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