Article
[Recent research on childhood hypertrophic cardiomyopathy caused by MYH7 gene mutations].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics - 15 Apr 2023
Zheng Kui, Liu Lu, Zhang Ying-Qian
Abstract excerpt
Hypertrophic cardiomyopathy (HCM) is the most common monogenic inherited myocardial disease in children, and mutations in sarcomere genes (such as MYH7 and MYBPC3) are the most common genetic etiology of HCM, among which mutations in the MYH7 gene are the most common and account for 30%-50%. MYH7 gene mutations have the characteristics of being affected by environmental factors, coexisting with multiple genetic...
Topics
- Child
- Humans
- Cardiomyopathy, Hypertrophic
- Phenotype
- Troponin T
- Mutation
- Carrier Proteins
- Myosin Heavy Chains
- Cardiac Myosins