Article
Novel homozygous variants in the TMC1 and CDH23 genes cause autosomal recessive nonsyndromic hearing loss.
Molecular genetics & genomic medicine - 1 Dec 2020
Zardadi Safoura, Razmara Ehsan, Asgaritarghi Golareh, Jafarinia Ehsan, Bitarafan Fatemeh, Rayat Sima, Almadani Navid, Morovvati Saeid, Garshasbi Masoud
Abstract excerpt
BACKGROUND: Hereditary hearing loss (HL) is a heterogeneous and most common sensory neural disorder. At least, 76 genes have been reported in association with autosomal recessive nonsyndromic HL (ARNSHL). Herein, we subjected two patients with bilateral sensorineural HL in two distinct consanguineous Iranian families to figure out the underlying genetic factors. METHODS: Physical and sensorineural examinations...
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