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Article

PAMAM-cRGD mediating efficient siRNA delivery to spermatogonial stem cells

1 Dec 2019

Abstract excerpt

BACKGROUND: Spermatogonial stem cells (SSCs) are the cornerstone of sperm production and thus perpetual male fertility. In clinics, transplantation of patient's own SSCs into testes is a promising technique to restore fertility when male germ cells have been depleted by gonadotoxic therapies. Auto-transplantation of genetically modified SSCs even has the potential to treat male infertility caused by genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 31852526
DOI: 10.1186/s13287-019-1506-4

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