Article
The Detection and Partial Localisation of Heteroplasmic Mutations in the Mitochondrial Genome of Patients with Diabetic Retinopathy.
International journal of molecular sciences - 11 Dec 2019
Malik Afshan N, Rosa Hannah S, de Menezes Eliane S, Tamang Priyanka, Hamid Zaidi, Naik Anita, Parsade Chandani Kiran, Sivaprasad Sobha
Abstract excerpt
Diabetic retinopathy (DR) is a common complication of diabetes and a major cause of acquired blindness in adults. Mitochondria are cellular organelles involved in energy production which contain mitochondrial DNA (mtDNA). We previously showed that levels of circulating mtDNA were dysregulated in DR patients, and there was some evidence of mtDNA damage. In the current project, our aim was to confirm the presence...
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