Article
Endoscopic ultrasound may be used to deliver gene expression signatures using digital mRNA detection methods to immunophenotype pancreatic ductal adenocarcinoma to facilitate personalized immunotherapy.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Mar 2020
Gleeson Ferga C, Levy Michael J, Jackson Rory A, Murphy Stephen J, Halling Kevin C, Kipp Benjamin R, Graham Rondell P, Zhang Lizhi
Abstract excerpt
BACKGROUND & OBJECTIVES: Biomarkers are increasingly required to molecularly characterize pancreatic ductal adenocarcinoma (PDAC) subgroup populations, to determine who may benefit from immune based targeted therapy. We evaluated the feasibility of gene expression signature detection and the respective landscape of specific tumor infiltrating lymphocytes (TILs), cancer/testis (CT) antigens, and immune checkpoints...
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