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Autophagy-activating strategies to promote innate defense against mycobacteria

1 Dec 2019

Abstract excerpt

Mycobacterium tuberculosis (Mtb) is a major causal pathogen of human tuberculosis (TB), which is a serious health burden worldwide. The demand for the development of an innovative therapeutic strategy to treat TB is high due to drug-resistant forms of TB. Autophagy is a cell-autonomous host defense mechanism by which intracytoplasmic cargos can be delivered and then destroyed in lysosomes. Previous studies have...

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PMID: 31827065
DOI: 10.1038/s12276-019-0290-7

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