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Article

A multi-genotype therapeutic human papillomavirus vaccine elicits potent T cell responses to conserved regions of early proteins.

Scientific reports - 10 Dec 2019

Hancock Gemma, Blight Joshua, Lopez-Camacho Cesar, Kopycinski Jakub, Pocock Mamatha, Byrne Wendy, Price Michael J, Kemlo Phillip, Evans Ranoromanana Ionitiana, Bloss Angela, Saunders Kathryn, Kirton Richard, Andersson Monique, Hellner Karin, Reyes-Sandoval Arturo, Dorrell Lucy

Abstract excerpt

Despite an efficacious prophylactic human papillomavirus (HPV) vaccine there is still a considerable global burden of HPV-related disease. Therapeutic vaccines that could prevent cancers in at-risk women are urgently needed. Most candidate therapeutic vaccines have focused on two high-risk (hr) HPV genotypes, 16 and 18, and two viral targets, E6 and E7, which may limit global coverage and efficacy. We designed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31822717
DOI: 10.1038/s41598-019-55014-z
PMCID: PMC6904585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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