Article
PD-L1 Expression in Pediatric Low-Grade Gliomas Is Independent of BRAF V600E Mutational Status.
Journal of neuropathology and experimental neurology - 1 Jan 2020
Martin Allison M, Bell W Robert, Yuan Ming, Harris Lauren, Poore Bradley, Arnold Antje, Engle Elizabeth L, Asnaghi Laura, Lim Michael, Raabe Eric H, Eberhart Charles G
Abstract excerpt
To evaluate a potential relationship between BRAF V600E mutation and PD-L1 expression, we examined the expression of PD-L1 in pediatric high- and low-grade glioma cell lines as well as a cohort of pediatric low-grade glioma patient samples. Half of the tumors in our patient cohort were V600-wildtype and half were V600E mutant. All tumors expressed PD-L1. In most tumors, PD-L1 expression was low (<5%), but in some...
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