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Article

Hypermethylation of NRG1 gene correlates with the presence of heart defects in Down's syndrome.

Journal of genetics - 1 Dec 2019

Dobosz Artur, Grabowska Agnieszka, Bik-Multanowski Miroslaw

Abstract excerpt

Congenital heart defects can decrease the quality of life and life expectancy in affected individuals, and constitute a major burden for the health care systems. Endocardial cushion defects are among the most prevalent heart malformations in the general population, and are extremely frequent (approximately a 100-fold higher prevalence) in children with Down syndrome. Several genes have been proposed to be...

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PMID: 31819021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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