Article
Redefining phenotypes to advance psychiatric genetics: Implications from hierarchical taxonomy of psychopathology.
Journal of abnormal psychology - 1 Feb 2020
Waszczuk Monika A, Eaton Nicholas R, Krueger Robert F, Shackman Alexander J, Waldman Irwin D, Zald David H, Lahey Benjamin B, Patrick Christopher J, Conway Christopher C, Ormel Johan, Hyman Steven E, Fried Eiko I, Forbes Miriam K, Docherty Anna R, Althoff Robert R, Bach Bo, Chmielewski Michael, DeYoung Colin G, Forbush Kelsie T, Hallquist Michael, Hopwood Christopher J, Ivanova Masha Y, Jonas Katherine G, Latzman Robert D, Markon Kristian E, Mullins-Sweatt Stephanie N, Pincus Aaron L, Reininghaus Ulrich, South Susan C, Tackett Jennifer L, Watson David, Wright Aidan G C, Kotov Roman
Abstract excerpt
Genetic discovery in psychiatry and clinical psychology is hindered by suboptimal phenotypic definitions. We argue that the hierarchical, dimensional, and data-driven classification system proposed by the Hierarchical Taxonomy of Psychopathology (HiTOP) consortium provides a more effective approach to identifying genes that underlie mental disorders, and to studying psychiatric etiology, than current diagnostic...
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