Hierarchical Phenotyping of Psychopathology: Implications and Opportunities for Precision Psychiatry When Biology Could Be Associated With Both Symptoms and Syndromes.

Abstract excerpt

As psychiatry increasingly embraces precision medicine principles, there have been efforts to characterize the specificity of biology-psychopathology associations (e.g., is biology associated with syndromes or symptoms?). Unfortunately, the vast majority of research is designed to test syndromes (e.g., case-control, symptom total/average scores) or individual symptoms a priori based on untested assumptions....

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