Article
Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway.
Autophagy - 1 Aug 2020
Qureshi-Baig Komal, Kuhn Diana, Viry Elodie, Pozdeev Vitaly I, Schmitz Martine, Rodriguez Fabien, Ullmann Pit, Koncina Eric, Nurmik Martin, Frasquilho Sonia, Nazarov Petr V, Zuegel Nikolaus, Boulmont Marc, Karapetyan Yervand, Antunes Laurent, Val Daniel, Mittelbronn Michel, Janji Bassam, Haan Serge, Letellier Elisabeth
Abstract excerpt
In solid tumors, cancer stem cells (CSCs) or tumor-initiating cells (TICs) are often found in hypoxic niches. Nevertheless, the influence of hypoxia on TICs is poorly understood. Using previously established, TIC-enrichedpatient-derived colorectal cancer (CRC) cultures, we show that hypoxia increases the self-renewal capacity of TICs while inducing proliferation arrest in their more differentiated counterpart...
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