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Article

Prenatal electroporation-mediated gene transfer restores Slc26a4 knock-out mouse hearing and vestibular function.

Scientific reports - 29 Nov 2019

Takeda Hiroki, Miwa Toru, Kim Min Young, Choi Byung Yoon, Orita Yorihisa, Minoda Ryosei

Abstract excerpt

The otocyst, an anlage of the inner ear, presents an attractive target to study treatment strategies for genetic hearing loss and inner ear development. We have previously reported that electroporation-mediated transuterine gene transfer of Connexin30, utilizing a monophasic pulse into Connexin30-/- mouse otocysts at embryonic day 11.5, is able to prevent putative hearing deterioration. However, it is not clear...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31784581
DOI: 10.1038/s41598-019-54262-3
PMCID: PMC6884448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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