Article
Mycobacterium tuberculosis strains of the modern Beijing sublineage excessively accumulate triacylglycerols in vitro.
Tuberculosis (Edinburgh, Scotland) - 1 Jan 2020
Tong Jingfeng, Liu Qingyun, Wu Jie, Jiang Yuan, Takiff Howard E, Gao Qian
Abstract excerpt
Mycobacterium tuberculosis (Mtb) strains of modern Beijing sublineage appear to be more transmissible and cause more severe disease than strains of other sublineages, but the responsible pathogenic mechanisms remain unclear. We previously identified genetic changes that are specific for the modern Beijing sublineage, and here we characterize the lipidome and transcriptome differences between modern and ancient...
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