Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies.

doi:10.3389/fimmu.2019.02603

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Article

Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies.

Frontiers in immunology - 1 Jan 2019

Ui Mhaonaigh Aisling, Coughlan Alice M, Dwivedi Amrita, Hartnett Jack, Cabral Joana, Moran Barry, Brennan Kiva, Doyle Sarah L, Hughes Katherine, Lucey Rosemary, Floudas Achilleas, Fearon Ursula, McGrath Susan, Cormican Sarah, De Bhailis Aine, Molloy Eleanor J, Brady Gareth, Little Mark A

Abstract excerpt

Low Density Granulocytes (LDGs), which appear in the peripheral blood mononuclear cell layer of density-separated blood, are seen in cancer, sepsis, autoimmunity, and pregnancy. Their significance in ANCA vasculitis (AAV) is little understood. As these cells bear the autoantigens associated with this condition and have been found to undergo spontaneous NETosis in other diseases, we hypothesized that they were key...

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PMID: 31781107
DOI: 10.3389/fimmu.2019.02603
PMCID: PMC6856659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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