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Article

What do functional genomics tell us about pathogenesis of AML?

Best practice & research. Clinical haematology - 1 Dec 2019

Tyner Jeffrey W, Bottomly Daniel, Wilmot Beth, McWeeney Shannon

Abstract excerpt

While molecular genetic abnormalities can tell us much about the pathogenesis of acute myeloid leukemia (AML), these molecular genetics do not always explain drug resistance or sensitivity, leaving room for other mechanisms of tumor pathogenesis outside of genetic events. The Beat AML 1.0 project was a multicenter project to sequence and functionally query AML samples against over 120 drugs. The results have...

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PMID: 31779979
DOI: 10.1016/j.beha.2019.101101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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