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A magic kick for regeneration: role of mesenchymal stromal cell secretome in spermatogonial stem cell niche recovery

21 Nov 2019

Abstract excerpt

BACKGROUND: Injury of stem cell niches may disturb tissue homeostasis and regeneration coordinated by specific niche components. Yet, the mechanisms of stem cell niche restoration remain poorly understood. Herein, we examined the role of mesenchymal stromal cells (MSCs) as pivotal regulators of stem cell niche recovery focusing on the effects of their secretome. METHODS: The spermatogonial stem cell (SSC) niche...

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PMID: 31753023
DOI: 10.1186/s13287-019-1479-3

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