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Article

Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease.

Structure (London, England : 1993) - 2 Oct 2018

Matthew Ashley N, Leidner Florian, Newton Alicia, Petropoulos Christos J, Huang Wei, Ali Akbar, KurtYilmaz Nese, Schiffer Celia A

Abstract excerpt

Despite significant progress in hepatitis C virus (HCV) protease inhibitor (PI) drug design, resistance remains a problem causing treatment failure. Double-substitution variants, notably Y56H/D168A, have emerged in patients who fail therapy with a PI-containing regimen. The resistance conferred by Asp168 substitutions has been well characterized and avoided in newer inhibitors. However, an additional mutation at...

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Identifiers

PMID: 30146168
DOI: 10.1016/j.str.2018.07.004
PMCID: PMC6260965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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