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Article

Fuzzy modeling and global optimization to predict novel therapeutic targets in cancer cells.

Bioinformatics (Oxford, England) - 1 Apr 2020

Nobile Marco S, Votta Giuseppina, Palorini Roberta, Spolaor Simone, De Vitto Humberto, Cazzaniga Paolo, Ricciardiello Francesca, Mauri Giancarlo, Alberghina Lilia, Chiaradonna Ferdinando, Besozzi Daniela

Abstract excerpt

MOTIVATION: The elucidation of dysfunctional cellular processes that can induce the onset of a disease is a challenging issue from both the experimental and computational perspectives. Here we introduce a novel computational method based on the coupling between fuzzy logic modeling and a global optimization algorithm, whose aims are to (1) predict the emergent dynamical behaviors of highly heterogeneous systems...

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PMID: 31750879
DOI: 10.1093/bioinformatics/btz868
PMCID: PMC7141866

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