Article
Transcriptional alteration of DNA repair genes in Philadelphia chromosome negative myeloproliferative neoplasms.
Annals of hematology - 1 Dec 2019
Kirschner Martin, Bornemann Anne, Schubert Claudia, Gezer Deniz, Kricheldorf Kim, Isfort Susanne, Brümmendorf Tim H, Schemionek Mirle, Chatain Nicolas, Skorski Tomasz, Koschmieder Steffen
Abstract excerpt
Philadelphia negative (Ph-neg) myeloproliferative neoplasms (MPN) are a heterogenous group of clonal stem cell disorders. Approved treatment options include hydroxyurea, anagrelide, and ruxolitinib, which are not curative. The concept of synthetic lethality may become an additional therapeutic strategy in these diseases. In our study, we show that DNA repair is altered in classical Ph-neg MPN, as analyzed by gene...
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