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Article

Single haplotype admixture models using large scale HLA genotype frequencies to reproduce human admixture.

Immunogenetics - 1 Nov 2019

Simanovsky Alexandra Litinsky, Madbouly Abeer, Halagan Michael, Maiers Martin, Louzoun Yoram

Abstract excerpt

The human leukocyte antigen (HLA) is the most polymorphic region in humans. Anthropologists use HLA to trace populations' migration and evolution. However, recent admixture between populations can mask the ancestral haplotype frequency distribution. We present a statistical method based on high-resolution HLA haplotype frequencies to resolve population admixture using a non-negative matrix factorization formalism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31741008
DOI: 10.1007/s00251-019-01144-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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