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Article

PTBP1-mediated regulation of AXL mRNA stability plays a role in lung tumorigenesis

15 Nov 2019

Abstract excerpt

AXL is expressed in many types of cancer and promotes cancer cell survival, metastasis and drug resistance. Here, we focus on identifying modulators that regulate AXL at the mRNA level. We have previously observed that the AXL promoter activity is inversely correlated with the AXL expression levels, suggesting that post-transcriptional mechanisms exist that down-regulate the expression of AXL mRNA. Here we show...

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PMID: 31729427
DOI: 10.1038/s41598-019-53097-2

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